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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4580ab9e5bb002bee2e39e09e5f3c0f553618f9a965e89b15b0775b2fac66468' 
  AND token = 'XmOmfwEOjjRRKd/1xImyeyzoU33Pcfs0cp4LzcOY+I0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}