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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '376492641be07cddd115293827a7d120b5379247ae2112805a2e9cff758af442' 
  AND token = 'O8/2ctT2wWBplSKT7pcGR5uGkzTdd2n6JVjaQYVb7Wc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}