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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44299d0bf3c5a7c23c50dddfabf0b956528e339a29de14286e8a49a3aacd86a9' 
  AND token = 'CIXra72AeInNspdx5xsg/yAd/WV8e7DYcQyAOSYfOUk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}