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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '454aa9230c3dc97f304f21ff66effa682e773427d03105dd6306ef569aa05c00' 
  AND token = 'ptU0nd//uzowvpCQ2/6IHMRFbtuAaOZ2pezC3vh+/a8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}