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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e0104ded5c7247b0625cf051d58a9c222b0f1856e6142bd901f1b3e52c28a74' 
  AND token = 'tyPrbG6BzuTPIz2eIJuJ2qbks/8q0PYZHDrVmmLbcvY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}