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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f8b613f3f791e482ac4624b3f7283fdcc4f2f1a3724075b91cc48ed49952a746' 
  AND token = 'UD4oZcLynt16VQyl+NR2zjYuZD6a+28B3+s/v18Bdwc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}