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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1509cb9e39487f7407e78015ed9a591c396f685b1dc39e23ba15220713d8c2b4' 
  AND token = 'Wn73kGzCX2M+UoX//2v0IYHVQejhFeTnP2igERrU5eg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}