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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '37c0a60cfb3ac9d04ad3512f3def3bd1f2974462ab653ce93d4649fa03b96af8' 
  AND token = 'uDPldcpdFv/iqzHb8S9zIVKsb5jIRcFRHn45M9gyPJM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}