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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7449b10dcbbf4bfd57ee7a863ff22f5f424fd6d28a7dec53e0a054f366723349' 
  AND token = 'o1Sn8psd2knt99hq/8hzZ6XRvQ1NDHq7Hkao3sTkFF4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}