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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c4e7f27b9b3a03ac25798f416338870c10cc9aba11e0c1b1341adc5260319d0' 
  AND token = 'vwsTJQ2tRoSYXfBjjkzH2fcFQ7Q/zMn9y6DiGiLJJtc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}