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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7f39a157cdb452a391a5169e5c1e239b841e5bb5edc4d12055bcfafb202863c5' 
  AND token = 'zeGPi+PIThSVaN/wgWXiPLh09B4Za1Ct9yY2Xsm+ygs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}