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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53cd5dbee89da7d765e5f714c5f25dceecee517d7f064c31a4d762e4c2a0bfc2' 
  AND token = 'ajTA6UkFxmvPL6Li6q75XmEZdq9d4iJjzq8ymAbCz7c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}