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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43f5de2ab73aa49a08474a80e8439bc070755d413b149b89e5115005e82e1296' 
  AND token = 'PKlxq5Z3G2dxcOeJdZax7v/xJCLhNCHc6d1V0X3rOEo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}