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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ae7b6c86b8480b5e6fbb4746dbe3222f38b95ad06bfd8e55c513009c885d6db' 
  AND token = 'HZJKQcQM/W7JDWQltDKvHqb5tVD9yTb1Lm5016n9sAo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}