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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '37ea73ab4a65d27a4e1a4934d0c44a1bb75814b2809bca6bb10d640ecac4b7d9' 
  AND token = 'r2zgAruy9VtBhkOv4XfyGCOLbhMbQWDMA+kdsRDv2z0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}