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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ea5b5b4c64049add6a5ed34f20b585a01250617d3c44450d72d99435ce299b4b' 
  AND token = '0P3rY81LAB4UM3IPw2V3go6tcmcT4HU+4AK9I4Cuaa8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}