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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '761078713e334138ded2a553363375eb1b0bb48aed60b4a56582139d560ce8c4' 
  AND token = 'GcXGVJ+t2+u7Nh6JVcDTvVk69rblIJHBuYlg/iD3C1Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}