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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c280e5a79ec98a6d453afd791f5794354b3c8b4123d1c129a4b50631e7b8a4c' 
  AND token = 'HUNLZpYuzThVIVDY6W45B3kOBkaa9BR2ZmCkhDT2IZo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}