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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '495cac486e9ddf7f837024540834d9753e302c90e0d037d9c0ba4ac4ff46c8b9' 
  AND token = 'z8EEh6fp+NXbpaSeSPwNziE1JA41GOHhRwfc/iHUfaY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}