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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '366c043449f7a0c197b06c8ace93913fccbf72d3227221879cf8840862a5c646' 
  AND token = 'dob2gYh+2n/gSUh2EhyTAPXSn1TYoFR39CzSWK1TGTM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}