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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221b648cf7203df255adc252f96e0d117e89a76da9c8bccd2fd7cfd5c80b429e' 
  AND token = 'wx0iTjnxhWNaMNR5Y+h+JKafDSuuXcw6vm/1nY/lgSc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}