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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f018e915902015beee110cd57a3a29916a9ca08f09a68b5c5259b8bb1b4971ea' 
  AND token = 'pJ7FDZXot+KpY9Y7pCgOHOG8fZyJCEBIDPy3MGtLT24=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}