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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cf5ada2211249c5461c92e16497e3570dfc8a16c9221bd8e527651237b60f8a0' 
  AND token = 'caonWmBNIV09JODkFhoN146yQcBus/RC/ITel9vsm2I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}