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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65df1e942ff5bae7bfa39be60ed24bba9e42eafed0d39e2ee64c8304163e3f3b' 
  AND token = 'RmFH3aeRqdIreMXw4G3uVKu6cb7mYbMyjZ1GXkGJP4E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}