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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5eb81b0449fe937e6e4e56bbb25044ea9d013cedbf313f16e8055bc2327f6254' 
  AND token = 'kmyf3Z+kIwf5CS1D2TSf10r5cK0HQXxFB0rPuB+qhhg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}