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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '257b41781412f0fd82a5cbf12d1f5d46994588caba428e735f17c786a55f1ee1' 
  AND token = 'BhmO44TLBl0lNIWoEC/Cq/k5WDgC2g3A+T3rnn/kGJQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}