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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8378d4d8d285b903004cab73d5dc9e8332c5326492e6f24ee4222db3de7fb765' 
  AND token = 'LPlSWigJewAkw/RocyworflKSYl4df4Y7VxpXJN3N40=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}