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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '24663e6c7c8b38ad459bfcc9d965fc6d278c8fdefab6821cd110d3a337f3f356' 
  AND token = 'D0R/Bjbs4I7LWXXay+bKciRf/MfSVE0N/Lj3T2QcReI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}