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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00e21880386259a24ba25b28c3467c39a5aefd0853ecc0903211c785ed0b5b53' 
  AND token = 'IQ5yQ028NAc9jSRAROLObeGKJzEZLZKCgyXfMXk7iaQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}