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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '424f1e303ece477a7507ec8532f2b3f5fe4499a998a1da0b60b275e2e0c9e645' 
  AND token = 'Fya5VpRBziMwI3HrS8BVUb8hwx91C07Y5FwxeT0uI+Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}