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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e754b469bb9950f8d30874beac26bed1fd4f97abf2f34914eea35f76a20d525' 
  AND token = 'AxatZftuT/32xjve9vfwC20g0JTgp+m7cyoCyxmCaQQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}