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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2277789cb04ead17d66bc390a04ee34b5c8641b0d9aa8f702171e6b13fb53d3b' 
  AND token = 'nNV73ec4XKUPoFWi5dWvdJf14mvZ+sAgK+oOMpwlPJU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}