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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d159eb4d16f81419c21e13974e082d6440534cf576bab356cd614bbbde6d50f' 
  AND token = '2/vgADZmgsS5Jr1qVpg7afGd/maSkziUk3CmMy/GOY4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}