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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fa8fc721b51cc4683c8ee3145aab6b2736775de4267944458e5655a0983a3bf0' 
  AND token = 'yREV+V148gSwtika6yz6oRKAf15+1NsJuun+S17B2Bg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}