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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a427c07d5111c27fbbc2f990f5e710cba435016a24a9675ad49daf5278a941e7' 
  AND token = 'd/UvDQyEfPxiOA++HMfo3Da73lZEIZ6EClhCUjCpVjM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}