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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c272a3fe29e174f2525e49a67e88de3c6ed7fc065789f6e88db0b0d1406d2056' 
  AND token = 'Eb1MQ67fnTx4mZGmMiSdXCqh6F/N1M2nyuKnciqeuNE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}