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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e2d3239e9a54a6c22e99ecaa3c7162751fad640b9a6411821e6d3e2dcc6da1dd' 
  AND token = 'kxUa1POW+xCU6PbwpGLl8rbrgUx3TAfhw67OL70nF/Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}