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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0545c4bfb6007998057a64d6f95f01d3480c9fdf25f6d4d3e1613c088f87d388' 
  AND token = 'l9TjxVaNFRostap0qybwTflNdsdvieto1AhXmNENPCI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}