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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd726d40d9e60698236b953cf9a45f4344c73edf95a1c0c3e1f5f605b06944163' 
  AND token = 'uKIqfl5hq99g1UM95VUAeXfaeWHIELX+Czqr9Z9GbFo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}