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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a4d1d4c77815fe936a95e0d3e71a21972250e0cc538dc5df94ec0503c79df619' 
  AND token = 'IioZL8IoD+N86GAGinPlyBKT+q04P1pBdxMVu3liuuk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}