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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52a383f1b566684cc0de08cf6d801ce2435cfc56e6b702a5dfbf197ce9f7c870' 
  AND token = 'vBz8tf0ZhMYUmU4F0kz4/2MrQXczqCYzaVWdE5/uv8g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}