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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd143ed5701fdbe02035aaaa6059c7695f1519f919bbd04ca0d17f0ef97eff41d' 
  AND token = 'C5hyvYbdN0vJIX7LsxZwW9JvM6sYqmAHlpiKkdnI3LA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}