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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e245f42eae7018efa4d06c72d6254f7377af31febe0c007c9baa03d138bf394d' 
  AND token = 'lFi8+3e1ZLEsCWwhtaij/oz6IezW21UpjjL726qqCM0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}