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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2045320d06e4c521137f50bbe0bfb3d2c334bf5e328c64c167bdd694b2b53821' 
  AND token = 'PVm/iixUZ8dkVifDsHPHlKU46eHV+h0c3Nn8dmXGnNU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}