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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d27fad9f7b5ad0546d06eb8fc84ff6c7eddaf20a660bb833511851c097b02b0' 
  AND token = 'V2xfTv6ZJsVsyOSTwXd/zfJn43lq+4yatAD7yk+4BOQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}