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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '455bdb22b7c18063f5c7d279be2f95396ffc32af6c51180b29ae5db9d31ac496' 
  AND token = 'G2ZLfQEzjUWx1SUBY8/l/BZdGkIQ11in9QEZvlpWayo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}