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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2149e8c0ad8471b69f47736b1cd00f67acbc59e3ec890957e1dcb8d754914303' 
  AND token = 'z5+nfDzvqu+aM+kTJEJrc5BjEAlbPg1qnnfu3R3Ln48=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}