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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '476c5d9d86059b4bb34bada3b435d1d57e4d00511ede7918b8e7de6472f82ab0' 
  AND token = 'JqQh7tHqjAbB8HCWJyqnUMnaUrs5XnVl3+Dqv/x7p1o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}