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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7dc6b3c259cec750b0f161bdc385ca2bdb9989338aeff714021830e8c6cbc189' 
  AND token = 'hEwHPPretZShKWsDBQSfgiYUUF4hA9skOhMipg37REo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}