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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4c225e498b3208a1f86e88d6ad79c736f6007ddad7e5ab9a37a7a89153c2166' 
  AND token = 'QPmk5t0oXQKjvSbHzN7kTT+CHz5FBBp6EsfR7RqTYB4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}